December 1, 1980The Journal of PhysiologyOpen Access

Relationship of arterial pressure and heart rate in fetal, new‐born and adult sheep.

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Why the study?

Does developmental stage affect baroreflex sensitivity in sheep?

Population

9 fetal, 4 new-born, and 6 adult sheep

Comparison

Raising arterial pressure via balloon inflation… vs Comparison across developmental stages and…

Design

Preclinical

Authors

GDG. S. DawesJohn Radcliffe Hospital BJBarbara M. JohnstonGriffith University DWD.W. WalkerJohn Radcliffe Hospital

Discussion

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Implication

Baroreflex maturation in fetal sheep is hypothesis-generating; leaves open translation to human neonates and clinical relevance.

Structured PICO

Does developmental stage affect baroreflex sensitivity in sheep?

Population

9 fetal, 4 new-born, and 6 adult sheep

Intervention

Raising arterial pressure via balloon inflation in the dorsal aorta, rapid intravenous injection of phenylephrine or methoxamine, or slow intravenous infusion of methoxamine

Comparator

Comparison across developmental stages (fetal vs. new-born vs. adult) and methods of raising arterial pressure

Outcome

Baroreflex sensitivity (assessed using the relationship between heart period and arterial pressure)surrogate

Baroreflex sensitivity is significantly lower in fetal and new-born sheep compared to adults, with a higher threshold for activation before birth.

Cite This Study

Dawes et al. (1980) studied this question.

synapsesocial.com/papers/6a79ec1c02ab7a73dd02a05d https://doi.org/10.1113/jphysiol.1980.sp013516

View Full Paper

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Bookmark

Relationship of arterial pressure and heart rate in fetal, new‐born and adult sheep.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Relationship of arterial pressure and heart rate in fetal, new‐born and adult sheep.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider