Comparison of Multiple Biomarkers for Mortality Prediction in Patients with Acute Heart Failure of Ischemic and Nonischemic Etiology

AIM: To investigate the prognosis of soluble ST2 (sST2), galectin-3 and N-terminal pro-B-type natriuretic peptide (NT-proBNP) for death related to ischemic and nonischemic etiology of acute heart failure (HF). METHODS: The associations between biomarkers and death were determined in 1020 patients admitted to hospital with acute HF. RESULTS: During 1-year follow-up, 162 patients died. Multivariable regression analysis showed that the hazard ratios of sST2 and NT-proBNP for 1-year all-cause death was similar and remained significant between ischemic and nonischemic HF patients. However, galectin-3 was not significantly associated with death when sST2 and NT-proBNP were incorporated into model in ischemic HF patients. CONCLUSION: There is no etiology dependent prognostic ability of NT-proBNP or ST2 in patients with acute HF, but for galectin-3 there is no added prognostic ability in ischemic HF.