Key result
Premature senescence markers positively correlated with atrial fibrotic lesions, and a lower P16/TGF-β ratio was found in patients with recurrent atrial fibrillation after surgical ablation.
Why the study?
Is premature senescence associated with atrial fibrosis and AF recurrence after surgical ablation in patients with atrial fibrillation?
Population
72 patients providing left atrial appendage tissue specimens, including groups with sinus rhythm, paroxysmal…
Comparison
Assessment of premature senescence markers and… vs Sinus rhythm vs. paroxysmal AF vs. persistent…
Design
Cohort
Follow-up
12 months
Authors
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May link fibroblast senescence to AF fibrosis; leaves open causal role and therapeutic targeting.
Observational (n=72)
Is premature senescence associated with atrial fibrosis and AF recurrence after surgical ablation in patients with atrial fibrillation?
Premature senescence is positively correlated with atrial fibrosis in AF, and a lower P16/TGF-β ratio is associated with AF recurrence after surgical ablation, suggesting a potential antifibrotic role.
Xie et al. (2017) conducted an observational in Atrial fibrillation (n=72). Premature senescence vs. Lower levels of senescence markers was evaluated on Atrial fibrosis and recurrence of atrial fibrillation. Premature senescence markers positively correlated with atrial fibrotic lesions, and a lower P16/TGF-β ratio was found in patients with recurrent atrial fibrillation after surgical ablation.
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