Key result
Elevated p21 expression, a marker of cellular senescence, was a significant independent predictor of early atrial fibrillation recurrence after the maze procedure (OR 2.97).
Why the study?
Accelerated senescence contributes to AF, but its specific role and the extent to which it aggravates the AF process required further understanding.
Does cellular senescence contribute to deleterious atrial remodeling and predict recurrence in patients with atrial fibrillation?
Observational (n=158)
No
Does cellular senescence contribute to deleterious atrial remodeling and predict recurrence in patients with atrial fibrillation?
Odds Ratio: 2.97 (95% CI 1.65–5.34)
p-value: p=<0.001
Atrial fibrillation induces cardiomyocyte senescence, which contributes to deleterious atrial remodeling and independently predicts early AF recurrence after surgical ablation.
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p21-associated senescence may drive post-ablation remodeling; hypothesis-generating in Level 5 data and requires prospective validation.
A 2022 study conducted an observational in Atrial Fibrillation (n=158). Elevated p21 expression (cellular senescence) vs. Lower p21 expression was evaluated on Early AF recurrence within 3 months after surgical ablation (OR 2.97, 95% CI 1.65-5.34, p=<0.001). Elevated p21 expression, a marker of cellular senescence, was a significant independent predictor of early atrial fibrillation recurrence after the maze procedure (OR 2.97).
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