Key result
Administration of asymmetric dimethylarginine (1 or 2 mg/kg/day) significantly decreased serum levels of inflammatory cytokines TNF-α, IL-6, and IL-10 in rats compared to control (p<0.001).
Why the study?
Does asymmetric dimethylarginine (ADMA) reduce inflammatory cytokines (TNF-α, IL-6, IL-10) in Wistar rats?
Population
30 Wistar adult albino rats
Comparison
Asymmetric dimethylarginine 1 mg/kg/day or 2… vs 0.9% sodium chloride
Design
Preclinical
Follow-up
7 days
Authors
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Suggests immunomodulatory effects in rats; hypothesis-generating and leaves open human translation.
Does asymmetric dimethylarginine (ADMA) reduce inflammatory cytokines (TNF-α, IL-6, IL-10) in Wistar rats?
p-value: p=< 0.001
Administration of ADMA in rats significantly decreases serum levels of inflammatory cytokines IL-6, TNF-α, and IL-10, indicating an immunosuppressive effect.
Avcı et al. (2013) studied this question. Asymmetric dimethylarginine (ADMA) vs. 0.9% sodium chloride was evaluated on Serum levels of TNF-α, IL-6 and IL-10 (p=< 0.001). Administration of asymmetric dimethylarginine (1 or 2 mg/kg/day) significantly decreased serum levels of inflammatory cytokines TNF-α, IL-6, and IL-10 in rats compared to control (p<0.001).
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