Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 9, 2022BMC NeurologyOpen Access

Influence of tirofiban on stroke outcome after mechanical thrombectomy in acute vertebrobasilar artery occlusion

View Full Paper
Ask AI
Bookmark
Share

Key result

In patients with acute vertebrobasilar artery occlusion undergoing mechanical thrombectomy, adjunctive tirofiban was not associated with an increased risk of symptomatic intracerebral hemorrhage (adjusted OR 0.96, 95% CI 0.12-7.82, p=0.97).

Why the study?

Patients with acute vertebrobasilar artery occlusion have high mortality despite mechanical thrombectomy, and the safety and efficacy of adjunctive tirofiban in this setting were unclear.

Does tirofiban improve clinical outcomes or increase bleeding risk in patients with acute vertebrobasilar artery occlusion undergoing mechanical thrombectomy?

Population

130 consecutive patients with acute vertebrobasilar artery occlusion receiving mechanical thrombectomy

Comparison

Adjunctive tirofiban vs no tirofiban

Design

Prospective registry-based cohort study

Follow-up

3 months

Authors

XPXiding PanChina Pharmaceutical UniversityMXMengyi XuJiangnan UniversityYFYuxiang FeiChina Pharmaceutical University

Discussion

Loading...

Member takes

Implication

Tirofiban adjunctive to MT was not associated with better outcomes in AVBAO; leaves open efficacy pending prospective trials.

Study Design

Type

Observational (n=130)

Multicenter

Yes

Structured PICO

Does tirofiban improve clinical outcomes or increase bleeding risk in patients with acute vertebrobasilar artery occlusion undergoing mechanical thrombectomy?

P
Population
130 patients (mean age 66.5 years, 26.2% female) with acute vertebrobasilar artery occlusion undergoing mechanical thrombectomy, followed for 3 months.
E
Exposure
Tirofiban adjunctive to mechanical thrombectomy (0.25-1 mg intra-arterial bolus, followed by continuous intravenous administration for 16-24 h at a rate of 0.1-0.15 μg/kg/min).
C
Comparator
Mechanical thrombectomy without adjunctive tirofiban.
O
Outcome
Short-term outcomes: symptomatic intracerebral hemorrhage (sICH), in-hospital death, and National Institute of Health Stroke Scale (NIHSS) at discharge. Long-term outcomes: modified Rankin Scale (mRS) at 3 months and death at 3 months.hard clinical

Main Result

Odds Ratio: 0.96 (95% CI 0.12–7.82)

Absolute Event Rate: 4.7% vs 12.1%

p-value: p=0.97

Adjunctive use of tirofiban during mechanical thrombectomy for acute vertebrobasilar artery occlusion does not appear to improve short- or long-term clinical outcomes or increase the risk of symptomatic intracerebral hemorrhage.

Limitations

  • Retrospective analysis of a prospective observational study with a limited number of patients
  • Specific dosage varied for individual use and was mainly determined by clinician's personal assessment
  • Prior antithrombotic agents use was not recorded
  • All patients were enrolled in China, limiting generalizability to global populations
  • Specific dosage varied for individual use and was determined by clinician's personal assessment
  • All patients were enrolled in China, so findings may not be applicable to global populations

Cite This Study

Pan et al. (2022) conducted an observational in Acute vertebrobasilar artery occlusion (n=130). Tirofiban vs. Standard mechanical thrombectomy without tirofiban was evaluated on Symptomatic intracerebral hemorrhage (sICH) (adjusted OR 0.96, 95% CI 0.12-7.82, p=0.97). In patients with acute vertebrobasilar artery occlusion undergoing mechanical thrombectomy, adjunctive tirofiban was not associated with an increased risk of symptomatic intracerebral hemorrhage (adjusted OR 0.96, 95% CI 0.12-7.82, p=0.97).

synapsesocial.com/papers/6a79f3452eb3c7e469f3c9eahttps://doi.org/10.1186/s12883-022-02996-5
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Safety and efficacy of tirofiban combined with endovascular treatment in acute ischaemic stroke2019 · 72 citations
  2. 2Safety and Efficacy of Intra-arterial Tirofiban Injection During Mechanical Thrombectomy for Large Artery Occlusion2019 · 23 citations
  3. 3The efficacy and risk factors of mechanical thrombectomy for the treatment of vertebrobasilar artery occlusion: a single center study2021 · 3 citations
  4. 4Endovascular Therapy for Ischemic Stroke with Perfusion-Imaging Selection2015 · 5,908 citations
  5. 5Safety and Efficiency of Low Dose Intra-arterial Tirofiban in Mechanical Thrombectomy During Acute Ischemic Stroke2018 · 39 citations