Key result
Tirofiban during mechanical thrombectomy linked to ~5-fold higher extracranial bleeding with no difference in ICH.
Why the study?
Many patients fail to achieve functional independence after mechanical thrombectomy despite recanalisation, potentially due to incomplete microvascular reperfusion that periprocedural tirofiban might improve.
Does periprocedural tirofiban improve recanalisation or increase bleeding in patients undergoing mechanical thrombectomy for large vessel occlusion?
Population
186 patients who underwent MT at North Bristol NHS Trust
Comparison
MT with periprocedural tirofiban vs without periprocedural tirofiban
Design
Retrospective cohort study
Follow-up
6-month
Authors
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Should not yet change practice for tirofiban in acute stroke; leaves open net benefit pending randomized trials.
Cohort (n=186)
No
Does periprocedural tirofiban improve recanalisation or increase bleeding in patients undergoing mechanical thrombectomy for large vessel occlusion?
Absolute Event Rate: 30% vs 25.3%
Periprocedural tirofiban during mechanical thrombectomy for large vessel occlusion was associated with increased extracranial bleeding and radiological mass effect without improving recanalisation success or mortality.
Timperley et al. (2026) conducted a cohort in Large vessel occlusion undergoing mechanical thrombectomy (n=186). Periprocedural tirofiban vs. No tirofiban was evaluated on Intracranial haemorrhage. Periprocedural tirofiban during mechanical thrombectomy did not significantly affect intracranial haemorrhage (30% vs 25.3%) but was associated with higher rates of extracranial bleeding (15.0% vs 3.0%, p=0.013).
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