Why the study?
Does prothrombin complex concentrate combined with intravenous vitamin K reverse severe warfarin-induced overanticoagulation and stop major bleeding in patients with INR > 14?
Population
10 patients presenting with major bleeding and severe warfarin-induced overanticoagulation
Design
Case_series, open-label
Follow-up
immediate
Authors
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May support urgent PCC plus vitamin K reversal in severe warfarin bleeding; hypothesis-generating and requires prospective confirmation.
Does prothrombin complex concentrate combined with intravenous vitamin K reverse severe warfarin-induced overanticoagulation and stop major bleeding in patients with INR > 14?
Prothrombin complex concentrate combined with intravenous vitamin K rapidly and effectively reverses severe warfarin-induced overanticoagulation and stops major bleeding without acute thromboembolic complications.
Evans et al. (2001) studied this question.
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