Key result
Enterovirus RNA positivity in blood during the 6 months preceding first autoantibody detection was strongly associated with the development of type 1 diabetes (OR 7.7; 95% CI 1.9-31.5).
Why the study?
Does the detection of enterovirus RNA in blood predict the development of clinical type 1 diabetes in children?
Case-Control (n=178)
Does the detection of enterovirus RNA in blood predict the development of clinical type 1 diabetes in children?
Odds Ratio: 7.7 (95% CI 1.9–31.5)
Absolute Event Rate: 5.1% vs 1.9%
p-value: p=<0.01
Enterovirus infection, particularly preceding autoantibody positivity, is significantly associated with the initiation and development of type 1 diabetes in children.
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Enterovirus RNA may precede T1D autoimmunity; hypothesis-generating for viral triggers but does not support predictive testing or prevention.
Oikarinen et al. (2010) conducted a case-control in Type 1 diabetes (n=178). Enterovirus RNA in blood vs. Absence of enterovirus RNA was evaluated on Enterovirus RNA positivity in serum samples (OR 7.7, 95% CI 1.9-31.5, p=<0.01). Enterovirus RNA positivity in blood during the 6 months preceding first autoantibody detection was strongly associated with the development of type 1 diabetes (OR 7.7; 95% CI 1.9-31.5).
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