Key result
Enterovirus infection in children genetically susceptible to type 1 diabetes induced a 339-gene transcriptomic signature characterized by strong activation of interferon and adaptive immune responses.
Observational (n=56)
Enterovirus infection in children with genetic susceptibility to type 1 diabetes induces individual-specific transcriptomic changes, including a strong interferon response in a subset of patients.
No takes yet. Share an insight, caveat, or question.
Enterovirus may elicit individualized interferon or adaptive immune transcriptomic responses in at-risk children; hypothesis-generating for progression to type 1 diabetes.
Lietzén et al. (2017) conducted an observational in Genetic susceptibility to type 1 diabetes (n=56). Enterovirus infection vs. Enterovirus-negative samples was evaluated on Enterovirus-associated changes in whole-blood transcriptomic profiles. Enterovirus infection in children genetically susceptible to type 1 diabetes induced a 339-gene transcriptomic signature characterized by strong activation of interferon and adaptive immune responses.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: