November 7, 2012PLoS ONEOpen Access

Enterovirus RNA in Peripheral Blood May Be Associated with the Variants of rs1990760, a Common Type 1 Diabetes Associated Polymorphism in IFIH1

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Structured PICO

Population

1,001 healthy children from the Norwegian MIDIA study (Environmental Triggers of Type 1 Diabetes), median age 12.3 months, 512 females, 489 males. 646 carrying highest-risk HLA genotype for T1D, 355 carrying other HLA genotypes.

Outcome

Frequency of enterovirus RNA in peripheral bloodsurrogate

The common IFIH1 SNP rs1990760 modifies the frequency of enterovirus RNA in the blood of healthy children, potentially explaining its association with type 1 diabetes.

Limitations

Material is probably not optimal to determine an exact genetic model
Lower statistical power due to the low frequency of rare alleles

Discussion

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Implication

IFIH1 rs1990760 genotype was associated with enterovirus RNA frequency in children; leaves open its role in type 1 diabetes pathogenesis.

Cite This Study

Cinek et al. (2012) studied this question.

synapsesocial.com/papers/6a95a25d7869fee11f8f1d4d https://doi.org/10.1371/journal.pone.0048409

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Enterovirus RNA in Peripheral Blood May Be Associated with the Variants of rs1990760, a Common Type 1 Diabetes Associated Polymorphism in IFIH1

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Enterovirus RNA in Peripheral Blood May Be Associated with the Variants of rs1990760, a Common Type 1 Diabetes Associated Polymorphism in IFIH1

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

Also Consider