Key result
Among 153 candidate SNPs, there was no clear evidence for strong associations with enterovirus presence in stool samples from Norwegian children.
Why the study?
Are established T1D susceptibility SNPs and innate immune gene SNPs associated with the frequency of enterovirus infection in healthy children?
Observational (n=792)
Are established T1D susceptibility SNPs and innate immune gene SNPs associated with the frequency of enterovirus infection in healthy children?
There is no strong evidence that established T1D susceptibility SNPs or candidate innate immunity SNPs are associated with the frequency of enterovirus infections in Norwegian children.
This is the authors' abstract. We don't add key points for this paper.
Enteroviruses have been suggested as triggers of type 1 diabetes (T1D). We aimed to assess whether established T1D susceptibility single nucleotide polymorphisms (SNPs) and candidate SNPs in innate immune genes were associated with the frequency of enterovirus infection in otherwise healthy children. Fifty-six established T1D SNPs and 97 other candidate immunity SNPs were typed in 419 children carrying the T1D high-risk genotype, HLA-DR4-DQ8/DR3-DQ2 genotype, and 373 children without this genotype. Enteroviral RNA was detected using real-time polymerase chain reaction, with primers detecting essentially all enterovirus serotypes, in 7,393 longitudinal stool samples collected monthly (age range 3-36 months). The most significant association was with two T1D SNPs, rs12150079 (ZPBP2/ORMDL3/GSDMB region) (enterovirus frequency: AA 7.3%, AG 8.7%, GG 9.7%, RR = 0.86, overall p = 1.87E-02) and rs229541 (C1QTNF6/SSTR3/RAC2) (enterovirus frequency: CC 7.8%, CT 9.7%, TT 9.4%, RR = 1.13, overall p = 3.6E-02), followed by TLR8 (rs2407992) (p = 3.8E-02), TLR3 (1914926) (p = 4.9E-02), and two other T1D SNPs (IFIH1 rs3747517, p = 4.9E-02 and PTPN22, rs2476601, p = 5.3E-02). However, the quantile-quantile plot of p-values with confidence intervals for all 153 SNPs did not reveal clear evidence for rejection of the complete null hypothesis. Among a number of SNPs in candidate genes, we found no evidence for strong associations with enterovirus presence in stool samples from Norwegian children.
Answers are grounded in this paper and cite their sources.
No candidate SNPs linked to enterovirus presence; hypothesis-generating for host genetics in pediatric viral carriage, requiring larger prospective studies.
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Witsø et al. (2015) conducted an observational in Enterovirus infection (n=792). T1D susceptibility SNPs and candidate SNPs in innate immune genes vs. Alternative genotypes was evaluated on Frequency of enterovirus infection (RR 0.86, p=1.87E-02). Among 153 candidate SNPs, there was no clear evidence for strong associations with enterovirus presence in stool samples from Norwegian children.
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