Key result
Neonatal coxsackievirus B3 infection in mice resulted in viral RNA persistence and chronic inflammatory lesions in the central nervous system for up to 9 months post-infection.
Population
1-day-old or 3-day-old BALB/c mouse pups
Comparison
Intracranial inoculation with 10^4 PFU of… vs Mock-infected control animals
Design
Preclinical
Follow-up
up to 9 months postinfection
Authors
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May indicate risk of chronic CNS sequelae after neonatal enterovirus; hypothesis-generating and requires human validation before any clinical implications.
Neonatal coxsackievirus B3 infection in a mouse model leads to long-term viral RNA persistence and chronic inflammatory lesions in the central nervous system, suggesting potential long-lasting neurological consequences.
Feuer et al. (2009) studied Neonatal coxsackievirus B3 (CVB3) infection. Coxsackievirus B3 (CVB3) infection vs. Mock infection was evaluated on Viral RNA persistence and chronic immunopathology in the CNS. Neonatal coxsackievirus B3 infection in mice resulted in viral RNA persistence and chronic inflammatory lesions in the central nervous system for up to 9 months post-infection.
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