January 30, 2004Diabetic Medicine

Isolation of enterovirus strains from children with preclinical Type 1 diabetes

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Why the study?

Is enterovirus infection associated with the development of diabetes-associated autoantibodies in children?

Structured PICO

Is enterovirus infection associated with the development of diabetes-associated autoantibodies in children?

Population

65 children from the Finnish Type 1 Diabetes Prediction and Prevention Study (DIPP) birth cohort, comprising 12 children who turned positive for diabetes-associated autoantibodies (cases) and 53 controls matched for date of birth, sex, and HLA-DQB1 alleles.

Comparator

Matched control children without diabetes-associated autoantibodies

Outcome

Presence of enterovirus infection (detected by RNA in stools and antibodies/RNA in serum) before the appearance of autoantibodiessurrogate

Enterovirus infections are significantly more frequent in children before the appearance of Type 1 diabetes-associated autoantibodies, suggesting a potential role in beta-cell damage.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Does not support practice changes; hypothesis-generating for enterovirus as trigger of islet autoimmunity.

Cite This Study

Salminen et al. (2004) studied this question.

synapsesocial.com/papers/6a79fc47f48aafa9d7f375cf https://doi.org/10.1111/j.1464-5491.2004.01097.x

View Full Paper

Ask AI

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Isolation of enterovirus strains from children with preclinical Type 1 diabetes

Structured PICO

Discussion

Implication

Cite This Study

Isolation of enterovirus strains from children with preclinical Type 1 diabetes

Structured PICO

Discussion

Implication

Cite This Study

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