Why the study?
Does low-molecular-weight heparin reduce platelet activation compared to unfractionated heparin in healthy volunteers?
Population
Healthy volunteers
Comparison
Low-molecular-weight heparin applied… vs Unfractionated heparin applied intravenously in…
Design
Other
Authors
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May inform heparin selection to limit platelet activation; leaves open clinical outcome impact in patients.
Does low-molecular-weight heparin reduce platelet activation compared to unfractionated heparin in healthy volunteers?
Low-molecular-weight heparin exhibits reduced platelet activating activity compared to unfractionated heparin, with the effect disappearing below 3,000 daltons.
Heinrich et al. (2009) studied this question.