Why the study?
Does Tinzaparin have a different effect on platelet aggregation compared to unfractionated heparin in vitro and ex vivo?
Population
In vitro and ex vivo platelet models
Comparison
Tinzaparin administered in vitro, intravenously… vs Unfractionated heparin administered in vitro and…
Design
Preclinical
Authors
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Animal data on differential platelet effects should not change heparin selection; hypothesis-generating for human relevance.
Does Tinzaparin have a different effect on platelet aggregation compared to unfractionated heparin in vitro and ex vivo?
Tinzaparin demonstrates a less proaggregatory effect on platelets than unfractionated heparin, suggesting a potentially favorable platelet activation profile.
Ravn et al. (1996) studied this question.
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