Why the study?
Does tinzaparin inhibit endothelial cell tube formation in human umbilical vein endothelial cells?
Population
Human umbilical vein endothelial cells (HUVEC) model of angiogenesis-mediated processes
Comparison
Tinzaparin and recombinant tissue factor pathway… vs Recombinant tick anticoagulant protein and…
Design
Preclinical
Authors
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Tinzaparin's TFPI-mediated anti-angiogenic effects in this model warrant further study; leaves open clinical translation or therapeutic relevance.
Does tinzaparin inhibit endothelial cell tube formation in human umbilical vein endothelial cells?
The anti-angiogenic effect of the low molecular weight heparin tinzaparin is mediated by the release of tissue factor pathway inhibitor rather than its anti-Factor Xa activity.
Mohamed et al. (2004) studied this question.
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