March 1, 2002Journal of Biological ChemistryOpen Access

Inactive Lipoprotein Lipase (LPL) Alone Increases Selective Cholesterol Ester Uptake in Vivo, Whereas in the Presence of Active LPL It Also Increases Triglyceride Hydrolysis and Whole Particle Lipoprotein Uptake

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Population

Transgenic mice

Comparison

Expression of catalytically inactive lipoprotein… vs Presence versus absence of active LPL in the…

Design

Preclinical

Follow-up

Evaluated at 18 hours of age and in adult mice

Authors

MMMartin MerkelUniversitäres Kinderwunschzentrum Lübeck JHJörg HeerenUniversität Hamburg WDWiebke DudeckUniversität Hamburg

Discussion

Member takes

Implication

Hypothesis-generating for LPL interactions in lipid metabolism; leaves open translation to human dyslipidemia or therapy.

Structured PICO

Population

Transgenic mice (Mck-N-LPL bred onto heterozygous LPL-deficient [LPL1], LPL-deficient [LPL0], and heart-only active LPL [LPL0/He-LPL] backgrounds)

Intervention

Expression of catalytically inactive lipoprotein lipase (LPL) in muscle

Comparator

Presence versus absence of active LPL in the same tissue

Outcome

Triglyceride levels, muscle lipid droplet accumulation, whole particle lipoprotein uptake, and selective cholesterol ester uptakesurrogate

Inactive LPL requires the presence of active LPL in the same tissue to augment triglyceride hydrolysis and whole particle uptake, but can mediate selective cholesterol ester uptake independently.

Cite This Study

Merkel et al. (2002) studied this question.

synapsesocial.com/papers/6a7a009414b028facf0e19d5 https://doi.org/10.1074/jbc.m107914200

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Inactive Lipoprotein Lipase (LPL) Alone Increases Selective Cholesterol Ester Uptake in Vivo, Whereas in the Presence of Active LPL It Also Increases Triglyceride Hydrolysis and Whole Particle Lipoprotein Uptake

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inactive Lipoprotein Lipase (LPL) Alone Increases Selective Cholesterol Ester Uptake in Vivo, Whereas in the Presence of Active LPL It Also Increases Triglyceride Hydrolysis and Whole Particle Lipoprotein Uptake

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider