Key result
Intravenous gamma globulin did not significantly reduce short-term mortality compared to conventional therapy alone in children with acute viral myocarditis (12.5% vs 15%, p=0.2).
Why the study?
Does intravenous gamma globulin improve survival and left ventricular ejection fraction in children with acute viral myocarditis?
Cohort (n=36)
No
Does intravenous gamma globulin improve survival and left ventricular ejection fraction in children with acute viral myocarditis?
Absolute Event Rate: 12.5% vs 15%
p-value: p=0.2
In a retrospective cohort of children with acute viral myocarditis, the addition of IVIG to conventional therapy did not significantly improve short-term survival or mid-term LVEF recovery, though sicker patients were more likely to receive IVIG.
No takes yet. Share an insight, caveat, or question.
IVIG should not yet change practice in pediatric viral myocarditis; leaves open efficacy for randomized trials.
Atiq et al. (2014) conducted a cohort in Acute viral myocarditis (n=36). Intravenous gamma globulin (IVIG) vs. Conventional anti-congestive therapy alone was evaluated on Mortality prior to hospital discharge (p=0.2). Intravenous gamma globulin did not significantly reduce short-term mortality compared to conventional therapy alone in children with acute viral myocarditis (12.5% vs 15%, p=0.2).
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