Key result
The SYNTAX score was not independently associated with the presence of carotid lesions, significant carotid disease, or complex carotid plaque in patients with multivessel CAD (all P > 0.2).
Why the study?
Does the SYNTAX score predict the presence of carotid disease in patients with multivessel coronary artery disease?
Cross-Sectional (n=204)
Does the SYNTAX score predict the presence of carotid disease in patients with multivessel coronary artery disease?
p-value: p=> 0.2
In patients with multivessel coronary artery disease, the SYNTAX score does not correlate with the presence or severity of carotid atherosclerosis, suggesting independent atherosclerotic burdens in these vascular beds.
Does not support SYNTAX-based carotid screening in multivessel CAD; leaves open independent atherosclerotic burdens across beds.
BACKGROUND: Numerous reports have shown the relationship between carotid artery atherosclerosis and coronary artery disease (CAD). However, the association between complex CAD evaluated by SYNTAX score (SxScore) and prevalence of carotid lesion (CL) has not been fully investigated. We sought to assess the prevalence of carotid atherosclerosis in patients with multivessel CAD assessed by SxScore and the relationship between SxScore severity and features of carotid atherosclerosis. METHODS AND RESULTS: Subjects were 204 consecutive patients with multivessel CAD assessed by coronary angiography and no previous history of carotid atherosclerosis that underwent carotid ultrasound scan from June 2012 to 2013. Presence of CL, significant carotid disease (SCD) and carotid plaque morphology was evaluated. At least one CL was found in 159 patients (77.9%) with no significant difference among SxScore groups (P = 0.20 and P = 0.54, respectively). High prevalence of complex carotid plaque (CCP) was found without significant different distribution in SxScore groups (P = 0.69). Age was independently associated with the presence of CL [odds ratio (OR) 1.055; 95% confidence interval (CI): 1.015-1.097; P = 0.007] and SCD (OR 1.057; 95% CI: 1.008-1.097; P = 0.019). Age and diabetes were independently associated with CCP (OR 1.58; 95% CI: 1.023-1.095; P = 0.001; OR 1.848; 95% CI: 1.026-3.327; P = 0.041). SxScore was not independently associated with CL, SCD and CCP (all P > 0.2). CONCLUSIONS: We found high prevalence of CL in patients with multivessel complex CAD. However, SxScore does not seem to correlate with carotid atherosclerosis.
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Costanzo et al. (2013) conducted a cross-sectional in multivessel coronary artery disease (n=204). SYNTAX score vs. Lower SYNTAX score groups was evaluated on Presence of carotid lesion (CL), significant carotid disease (SCD), and complex carotid plaque (CCP) (p=> 0.2). The SYNTAX score was not independently associated with the presence of carotid lesions, significant carotid disease, or complex carotid plaque in patients with multivessel CAD (all P > 0.2).
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