What question did this study set out to answer?

To characterize the virological features, serological relationships, and natural transmission cycle of Isfahan virus, a candidate vesicular stomatitis virus serotype.

March 1, 1977American Journal of Tropical Medicine and Hygiene

Isfahan Virus, A New Vesiculovirus Infecting Humans, Gerbils, and Sandflies in Iran

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To characterize the virological features, serological relationships, and natural transmission cycle of Isfahan virus, a candidate vesicular stomatitis virus serotype.
Isolated viral strains from pools of Phlebotomus papatasi sandflies collected in Iran in 1975 and examined viral ultrastructure using electron microscopy.
Assessed serological cross-reactivity with Cocal, Piry, and Chandipura viruses using complement fixation and neutralization tests.
Surveyed human populations, wild gerbils, and domestic animals across multiple Iranian regions for the presence of virus-neutralizing antibodies.
Electron microscopy revealed bullet-shaped virions with truncated particles maturing at host plasma membranes, sharing biological traits and cross-reactivity with known vesiculoviruses.
Neutralizing antibodies were detected in wild Iranian gerbils but were entirely absent in domestic animal sera.
Human seroprevalence was extensive across Iran, with a 100% infection rate observed in residents over 5 years of age in the village of original viral isolation.

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Implication

Epidemiological survey reveals widespread Isfahan virus infection in humans and gerbils transmitted by sandflies, suggesting a unique transmission cycle of public health relevance.

Cite This Study

Tesh et al. (1977) studied this question.

synapsesocial.com/papers/6a7a0cdafb5b6b43000de49f https://doi.org/10.4269/ajtmh.1977.26.299

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Implication

Epidemiological survey reveals widespread Isfahan virus infection in humans and gerbils transmitted by sandflies, suggesting a unique transmission cycle of public health relevance.

Isfahan Virus, A New Vesiculovirus Infecting Humans, Gerbils, and Sandflies in Iran

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Discussion

Implication

Cite This Study

Isfahan Virus, A New Vesiculovirus Infecting Humans, Gerbils, and Sandflies in Iran

Key Points

Discussion

Implication

Cite This Study

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