Key result
Recent FMDV serotype A viruses isolated in 2012 and 2013 showed antigenic drift and a poor match with the predominantly used A/TUR/2006 vaccine strain, highlighting vaccine inadequacy.
Answers are grounded in this paper and cite their sources.
Currently circulating FMDV serotype A viruses in the Middle East show poor antigenic matching with the widely used A/TUR/2006 vaccine, highlighting the need for updated vaccines.
A new immunologically distinct strain (A-Iran-05) of foot-and-mouth disease virus serotype A emerged in the Middle East in 2003 that replaced the previously circulating strains (A-Iran-96 and A-Iran-99) in the region. This resulted in introduction of a new vaccine of this strain (A/TUR/2006) in 2006. Though this vaccine strain has been predominantly used to control FMD in the region, recent viruses isolated in 2012 and 2013 have shown antigenic drift and a poor match with it. In this study, we report the antigenic matching results and capsid sequence data of currently circulating viruses belonging to the SIS-10 and SIS-12 sub-lineages of A-Iran-05 (isolated in 2012 and 2013), highlighting the inadequacy of the currently used serotype A vaccines. Implications of these results in the context of FMD control in the Middle East are discussed.
No takes yet. Share an insight, caveat, or question.
Mahapatra et al. (2016) studied Foot-and-mouth disease. A/TUR/2006 vaccine strain was evaluated on Antigenic matching and capsid sequence data. Recent FMDV serotype A viruses isolated in 2012 and 2013 showed antigenic drift and a poor match with the predominantly used A/TUR/2006 vaccine strain, highlighting vaccine inadequacy.
Synapse has enriched 10 related papers. Consider them for comparative context: