Key result
Parametric perfusable tissue index (PTIVb) from a single 15O-H2O PET/CT scan correlated strongly with 15O-CO-derived PTI and nonlinear regression.
Why the study?
Can parametric perfusable tissue index (PTI) images be accurately generated from a single 15O-H2O PET/CT scan without an additional 15O-CO scan?
Observational (n=30)
No
Can parametric perfusable tissue index (PTI) images be accurately generated from a single 15O-H2O PET/CT scan without an additional 15O-CO scan?
Parametric perfusable tissue index images for myocardial viability can be accurately generated from a single 15O-H2O PET/CT scan, eliminating the need for an additional 15O-CO scan.
Answers are grounded in this paper and cite their sources.
May simplify viability imaging by avoiding extra CO scans; supports PTIVb derivation but leaves open prospective validation.
UNLABELLED: Perfusable tissue index (PTI) is a marker of myocardial viability and requires acquisition of transmission, (15)O-CO, and (15)O-H(2)O scans. The aim of this study was to generate parametric PTI images from a (15)O-H(2)O PET/CT scan without an additional (15)O-CO scan. METHODS: Data from 20 patients undergoing both (15)O-H(2)O and (15)O-CO scans were used, assessing correlation between PTI based on (15)O-CO (PTI(CO)) and on fitted blood volume fractions (PTI(Vb)). In addition, parametric PTI(Vb) images of 10 patients undergoing (15)O-H(2)O PET/CT scans were generated using basis-function methods and compared with PTI(Vb) obtained using nonlinear regression. Simulations were performed to study the effects of noise on PTI(Vb). RESULTS: Correlation between PTI(CO) and PTI(Vb) was high (r(2) = 0.73). Parametric PTI(Vb) correlated well with PTI(Vb) obtained using nonlinear regression (r(2) = 0.91). Simulations showed low sensitivity to noise (coefficient of variation < 10% at 20% noise). CONCLUSION: Parametric PTI images can be generated from a single (15)O-H(2)O PET/CT scan.
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Harms et al. (2011) conducted an observational in Ischemic cardiomyopathy (n=30). Parametric perfusable tissue index (PTIVb) derived from a single 15O-H2O PET/CT scan vs. Perfusable tissue index derived from additional 15O-CO scan (PTICO) and nonlinear regression was evaluated on Correlation and agreement between PTI based on fitted blood volume fractions (PTIVb) and PTI based on 15O-CO scans (PTICO) (r^2 = 0.73, ICC = 0.86, slope = 0.90, p=<0.001). Parametric perfusable tissue index (PTIVb) from a single 15O-H2O PET/CT scan correlated strongly with 15O-CO-derived PTI and nonlinear regression.
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