What question did this study set out to answer?

To examine the relationship between circulating T follicular helper and T peripheral helper cells, B-cell biomarkers, and disease activity in primary Sjögren syndrome.

March 1, 2021RMD OpenOpen Access

Association between T follicular helper cells and T peripheral helper cells with B-cell biomarkers and disease activity in primary Sjögren syndrome

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To examine the relationship between circulating T follicular helper and T peripheral helper cells, B-cell biomarkers, and disease activity in primary Sjögren syndrome.
Evaluated circulating T peripheral helper cells and related lymphocyte subsets in the peripheral blood of patients with primary Sjögren syndrome.
Assessed correlations between T peripheral helper cell frequencies and circulating B-cell biomarkers, specifically plasmablasts.
Circulating T peripheral helper cells are elevated in the blood of individuals with primary Sjögren syndrome relative to baseline levels.
Elevated frequencies of T peripheral helper cells correlate positively with circulating plasmablasts.

Implication

Observational analysis reveals elevated T peripheral helper cells correlate with circulating plasmablasts in primary Sjögren syndrome, suggesting a role in driving autoimmune B-cell activation.

Abstract

T peripheral helper (Tph) cells are a newly described subtype of T lymphocytes. They are elevated in the blood of patients with pSS and correlate with circulating plasmablasts.

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Cite This Study

Dupré et al. (2021) studied this question.

synapsesocial.com/papers/6a7a0ff22eb3c7e469f3d641 https://doi.org/10.1136/rmdopen-2020-001442

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Implication

Observational analysis reveals elevated T peripheral helper cells correlate with circulating plasmablasts in primary Sjögren syndrome, suggesting a role in driving autoimmune B-cell activation.

Abstract

T peripheral helper (Tph) cells are a newly described subtype of T lymphocytes. They are elevated in the blood of patients with pSS and correlate with circulating plasmablasts.

Association between T follicular helper cells and T peripheral helper cells with B-cell biomarkers and disease activity in primary Sjögren syndrome

Key Points

Implication

Abstract

Discussion

Cite This Study

Association between T follicular helper cells and T peripheral helper cells with B-cell biomarkers and disease activity in primary Sjögren syndrome

Key Points

Implication

Abstract

Discussion

Cite This Study

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