What is the clinical evidence from this study?

Study design: Other. Intervention: S107 vs. Control conditions. Primary outcome: Stabilization of the RyR1-FKBP12 complex.

January 17, 2013PLoS ONEOpen Access

Stabilization of the Skeletal Muscle Ryanodine Receptor Ion Channel-FKBP12 Complex by the 1,4-Benzothiazepine Derivative S107

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Key result

S107 reverses the harmful effects of redox active species on SR Ca2+ release in skeletal muscle by binding to RyR1 low affinity sites and stabilizing the RyR1-FKBP12 complex.

Population

Skeletal muscle homogenates and sarcoplasmic reticulum membrane fractions obtained from leg and back muscle…

Comparison

S107 at various concentrations vs Control conditions (absence of S107)

Design

Preclinical

Authors

YMYingwu MeiZhengzhou University LXLe XuChina West Normal University HKHenning F. KramerSpringhouse

Discussion

Member takes

Implication

S107 may protect skeletal muscle Ca2+ release in animal redox stress; leaves open translation to human RyR1 disorders.

Structured PICO

Population

Skeletal muscle homogenates and sarcoplasmic reticulum (SR) membrane fractions obtained from leg and back muscle of 2-3 month old rabbits

Intervention

S107 (2,3,4,5,-tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine) at various concentrations (e.g., 44 µM)

Comparator

Control conditions (absence of S107)

Outcome

Stability of the RyR1-FKBP12 complex and RyR1 single channel activitysurrogate

S107 stabilizes the RyR1-FKBP12 complex in skeletal muscle, reversing the harmful effects of redox active species on SR Ca2+ release.

Cite This Study

Mei et al. (2013) studied this question. S107 vs. Control conditions was evaluated on Stabilization of the RyR1-FKBP12 complex. S107 reverses the harmful effects of redox active species on SR Ca2+ release in skeletal muscle by binding to RyR1 low affinity sites and stabilizing the RyR1-FKBP12 complex.

synapsesocial.com/papers/6a7a136bb008f0cadf32495c https://doi.org/10.1371/journal.pone.0054208

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Stabilization of the Skeletal Muscle Ryanodine Receptor Ion Channel-FKBP12 Complex by the 1,4-Benzothiazepine Derivative S107

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Stabilization of the Skeletal Muscle Ryanodine Receptor Ion Channel-FKBP12 Complex by the 1,4-Benzothiazepine Derivative S107

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider