Key result
The progression of neurodegeneration in Parkinson's disease is driven by complex interactions between oxidative stress, cell death, neuroinflammation, and the renin-angiotensin system.
Why the study?
Parkinson's disease therapy has focused only on avoiding symptom progression rather than finding a complete reversion of the disease.
This review highlights the role of renin-angiotensin system imbalance and neuroinflammation in the progression of Parkinson's disease.
Answers are grounded in this paper and cite their sources.
Symptomatic PD management persists without cures; leaves open validation of cell-process targets from reviewed evidence.
OBJECTIVES: (SNpc) has been the main focus of study and PD therapies since ages. MATERIALS AND METHODS: In this manuscript, a systematic revision of experimental and clinical evidence of PD-associated cell process was conducted. RESULTS: Classically, the damage in the dopaminergic neuronal circuits of SNpc is favored by reactive oxidative/nitrosative stress, leading to cell death. Interestingly, the therapy for PD has only focused on avoiding the symptom progression but not in finding a complete reversion of the disease. Recent evidence suggests that the renin-angiotensin system imbalance and neuroinflammation are the main keys in the progression of experimental PD. CONCLUSION: The progression of neurodegeneration in SNpc is due to the complex interaction of multiple processes. In this review, we analyzed the main contribution of four cellular processes and discussed in the perspective of novel experimental approaches.
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Hernández-Baltazar et al. (2019) conducted a review in Parkinson's disease. The progression of neurodegeneration in Parkinson's disease is driven by complex interactions between oxidative stress, cell death, neuroinflammation, and the renin-angiotensin system.
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