Key result
Female sex in patients with a Fontan circulation was associated with a significantly higher rate of adverse events compared to male sex (43% vs 13%, p=0.040).
Why the study?
Sex differences regarding outcomes, cardiovascular dimensions, and functional capacity in patients with a Fontan circulation required assessment.
Does female sex compared to male sex affect clinical outcomes and cardiac function in patients with a Fontan circulation?
Population
60 Fontan patients aged ≥10 years (30 females)
Comparison
Female vs male Fontan patients
Design
Single-center prospective standardized cohort study
Follow-up
Median 5.75 (5.4–6.0) years
Authors
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Female Fontan patients had higher event rates; hypothesis-generating for sex-specific risk stratification in prospective studies.
Cohort (n=60)
No
Does female sex compared to male sex affect clinical outcomes and cardiac function in patients with a Fontan circulation?
Absolute Event Rate: 43% vs 13%
p-value: p=0.040
Female patients with a Fontan circulation have significantly worse event-free survival and functional capacity compared to males, highlighting the need for sex-specific risk stratification.
Meyer et al. (2021) conducted a cohort in Fontan circulation (n=60). Female sex vs. Male sex was evaluated on combined outcome variable of all-cause mortality, heart/heart-lung transplantation (including listing) and Fontan-related hospitalisation (p=0.040). Female sex in patients with a Fontan circulation was associated with a significantly higher rate of adverse events compared to male sex (43% vs 13%, p=0.040).
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