Characterization and z-score calculation of cardiovascular magnetic resonance imaging parameters in patients after the Fontan operation: A Fontan Outcome Registry using Cardiovascular Magnetic Resonance Examinations study
Why the study?
CMR offers valuable hemodynamic insights post-Fontan, but its use is limited by the absence of normative single ventricle data.
Population
885 healthier Fontan patients with 1156 CMR examinations from 18 institutions, plus 1595 patients with adverse outcomes
Comparison
Healthier Fontan patients vs patients with adverse outcomes, and children vs adults
Design
International registry-based modeling and validation study
Authors
Discussion
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Member takes
Implication
Fontan-specific CMR z-scores now available for healthier patients; leaves open prospective validation before clinical adoption.
Structured PICO
P
Population
2,480 patients post-Fontan operation from the FORCE registry, including 885 'healthier' patients (free of adverse outcomes, NYHA class I, mild or less valve disease, <30% aortopulmonary collateral burden; mean age 15.0 ± 7.6 years) and 1,595 patients with adverse outcomes (death, listing for transplantation, or multiorgan disease; mean age 16.1 ± 9.3 years).
O
Outcome
Fontan-specific z-scores for cardiovascular magnetic resonance (CMR) ventricular volume and functionsurrogate
The development of Fontan-specific CMR z-scores adjusting for ventricular morphology, gender, and body surface area may improve risk stratification in patients after the Fontan operation.
Cite This Study
Alsaied et al. (2024) studied this question.