Key result
Single LVs in Fontan patients exhibit better GCS but worse GLS versus single RVs.
Why the study?
The study sought to assess the feasibility of CMR feature-tracking in Fontan patients and analyze correlations between strain values and conventional CMR parameters, clinical findings, and biomarkers.
Does myocardial deformation measured by CMR-FT correlate with ventricular function, clinical course, and biomarkers in Fontan patients?
Comparison
Single left ventricle vs single right ventricle morphology
Design
Retrospective observational study
Authors
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May support morphology-specific surveillance in Fontan patients; hypothesis-generating and requires prospective validation before clinical adoption.
Observational (n=47)
No
Does myocardial deformation measured by CMR-FT correlate with ventricular function, clinical course, and biomarkers in Fontan patients?
Absolute Event Rate: -23.6% vs -20%
p-value: p=<0.001
CMR-FT is a feasible tool in Fontan patients, demonstrating that global circumferential strain correlates significantly with ventricular volumes, ejection fraction, and NT-pro-BNP levels.
Callegari et al. (2021) conducted an observational in Single ventricle (Fontan circulation) (n=47). Single Left Ventricle (SLV) morphology vs. Single Right Ventricle (SRV) morphology was evaluated on Global circumferential strain (GCS) (p=<0.001). In Fontan patients, single left ventricles exhibited significantly better global circumferential strain but worse global longitudinal strain compared to single right ventricles.
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