Key result
GLS in Fontan patients worsens by ~1.4% over two years despite preserved EF.
Why the study?
Attrition of ventricular function is well recognized in Fontan patients, but early detection of ventricular dysfunction remains difficult.
Does CMR feature tracking detect early worsening of cardiac function in Fontan patients before clinical decline?
Population
51 Fontan patients aged ≥ 10 years
Comparison
Combined dominant and hypoplastic ventricles vs dominant ventricle only over time
Design
Prospective standardized follow-up study
Follow-up
2 years
Authors
Loading...
GLS may detect subclinical deterioration missed by EF in stable Fontan patients; leaves open its prognostic value and role in surveillance.
Cohort (n=51)
Does CMR feature tracking detect early worsening of cardiac function in Fontan patients before clinical decline?
Absolute Event Rate: -15.9% vs -17.3%
p-value: p=0.041
CMR feature tracking detects early subclinical decline in ventricular strain in Fontan patients despite preserved ejection fraction and clinical status.
Meyer et al. (2019) conducted a cohort in Fontan patients (n=51). 2 years of follow-up vs. Baseline was evaluated on Global longitudinal strain (GLS) (p=0.041). Over 2 years of follow-up, global longitudinal strain in Fontan patients significantly worsened from -17.3% to -15.9% (P=0.041) despite preserved ejection fraction and clinical status.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: