Key result
Blacks with hypertension exhibit greater salt sensitivity, suppressed plasma renin, and more frequent target organ damage, suggesting the need for a more physiological approach to treatment.
The review highlights the unique pathophysiological features of hypertension in black populations, such as salt sensitivity and suppressed renin, and proposes a tailored physiological approach to treatment.
Highlights need for ethnicity-specific hypertension strategies in blacks; leaves open genetic versus environmental contributions to salt sensitivity.
Although the consequences of hypertension are universal, blacks (African-Americans or indigenous Africans) have been the subject of a differential approach to causation, outcome, and treatment. Blacks have a greater propensity to salt sensitivity and suppressed plasma renin suggesting a predisposition to sodium retention. Target organ damage is more frequent and blood pressure is more difficult to control. We explore potential underlying causes, both genetic and environmental, particularly in the South African population, and propose a more physiological approach to the treatment of resistant hypertension in blacks.
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Rayner et al. (2016) conducted a review in Hypertension. Blacks with hypertension exhibit greater salt sensitivity, suppressed plasma renin, and more frequent target organ damage, suggesting the need for a more physiological approach to treatment.
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