Key result
In young adults with acute ischemic stroke, systolic blood pressure decreased spontaneously during the first 48 hours, though admission blood pressure was higher in those with risk factors.
Observational (n=39)
No
In young patients with acute ischemic stroke, blood pressure falls spontaneously during the first 48 hours, suggesting that young patients without prior risk factors may serve as a useful model for understanding acute stroke-related hypertension.
Answers are grounded in this paper and cite their sources.
May inform BP targets in young acute ischemic stroke; leaves open need for prospective validation.
Pablo Bonardoa*, Fatima Pantiua, Anibal Chertcoffa, Luciana León Cejasa, Sol Pachaa, Claudia Uribe Rocaa, Glenda Ernsta, Manuel Fernández Pardala & Ricardo Reisinaa Neurology Department, Hospital Británico de Buenos Aires, Buenos Aires, ArgentinaPablo Bonardo: drafting/revising the manuscript, study concept and design, accepts responsibility for conduct of research and final approval.Fátima Pantiu: drafting/revising the manuscript, analysis or interpretation of data, accepts responsibility for conduct of research and final approval, acquisition of data.Aníbal Chertcoff: drafting/revising the manuscript, analysis or interpretation of data, accepts responsibility for conduct of research and final approval, acquisition of data.Luciana León Cejas: drafting/revising the manuscript, analysis or interpretation of data, accepts responsibility for conduct of research and final approval, acquisition of data.Sol Pacha: drafting/revising the manuscript, study concept and design, accepts responsibility for conduct of research and final approval.Claudia Uribe Roca: drafting/revising the manuscript, analysis or interpretation of data, accepts responsibility for conduct of research and final approval, acquisition of data.Glenda Ernst: drafting/revising the manuscript, analysis or interpretation of data, accepts responsibility for conduct of research and final approval, acquisition of data.Manuel Fernández Pardal: drafting/revising the manuscript, analysis or interpretation of data, accepts responsibility for conduct of research and final approval, acquisition of data.Ricardo Reisin: drafting/revising the manuscript, analysis or interpretation of data, accepts responsibility for conduct of research and final approval, acquisition of data.Pablo Bonardo pablobonardo@hotmail.com; pbonardo@hbritanico.com.arABSTRACTBackground: Approximately 80% of patients suffering an acute ischemic stroke develop transient hypertension. The physiopathological mechanism remains unclear. Due to the lack of vascular risk factors, young adults could be a useful model for understanding blood pressure (BP) evolution in this setting.Methods: Patients between 18 and 55 years old admitted with an acute ischemic stroke were included. BP was evaluated during the following 48 h. Hypertension was defined as: systolic blood pressure (SBP) ≥140 mmHg or diastolic blood pressure (DBP) ≥90 mmHg. Patients were divided into two groups: RF group included those who had a previous vascular risk factor and/or other medical condition known to affect the autonomic function; noRF group included patients without any of the previously stated conditions.Results: Thirty-nine patients were included: mean age: 44.26 years old, 21 were males (53.8%). Mean SBP and DBP at admission were 139.77 ± 5.35 mmHg (range: 90–243) and 84.44 ± 3.02 mmHg (range: 60–128), respectively; 43.58% patients were hypertensive at admission. SBP decreased significantly during the first 48 h (p = 0.044) for the entire population. RF group has higher SBP (p = 0.009) and DBP (p = 0.011) at admission than the noRF group.Conclusion: Most patients were normotensive at admission and BP fell spontaneously despite BP at admission. Young patients without medical conditions that could alter the autonomic system function could be a useful model for understanding acute hypertension in ischemic stroke.
No takes yet. Share an insight, caveat, or question.
Bonardo et al. (2017) conducted an observational in Acute ischemic stroke (n=39). Vascular risk factors or conditions affecting autonomic function vs. No vascular risk factors was evaluated on Systolic blood pressure (SBP) decrease during the first 48 h (p=0.044). In young adults with acute ischemic stroke, systolic blood pressure decreased spontaneously during the first 48 hours, though admission blood pressure was higher in those with risk factors.
Synapse has enriched 10 related papers. Consider them for comparative context: