In normal adult subjects, insulin-like growth factor-I and high-density lipoprotein-cholesterol are associated with increased aortic distensibility, whereas low-density lipoprotein-cholesterol is associated with aortic stiffening.
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Associations in normals suggest IGF-I/HDL may preserve aortic distensibility; hypothesis-generating, should not yet change practice.
Hopkins et al. (1993) studied this question.
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