What question did this study set out to answer?

To evaluate whether continuous versus pulsatile secretory patterns of growth hormone differentially regulate serum concentrations of cholesterol and apolipoproteins.

March 1, 1991Journal of Endocrinology

Evidence for the role of the secretory pattern of growth hormone in the regulation of serum concentrations of cholesterol and apolipoprotein E in rats

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Why the study?

Does the secretory pattern of growth hormone affect serum concentrations of cholesterol and apolipoprotein E in hypophysectomized rats?

Key Points

To evaluate whether continuous versus pulsatile secretory patterns of growth hormone differentially regulate serum concentrations of cholesterol and apolipoproteins.
Infused hypophysectomized adult male Sprague-Dawley rats with human growth hormone (hGH) for 5 days via an automatic intravenous delivery system.
Delivered identical daily hGH doses as either continuous infusion (female-like pattern) or eight daily pulses at 3-hour intervals (male-like pattern), with concurrent cortisol and L-thyroxine replacement.
Continuous hGH infusion significantly increased total serum cholesterol, HDL-cholesterol, and apolipoprotein E concentrations, whereas pulsatile hGH administration had no effect on HDL-cholesterol or apolipoprotein E.
Serum apolipoprotein B concentrations decreased to an equivalent extent under both continuous and pulsatile hGH administration regimens.
Serum levels of apolipoprotein A-I and triglycerides were unaffected by either mode of hGH delivery.

Structured PICO

Does the secretory pattern of growth hormone affect serum concentrations of cholesterol and apolipoprotein E in hypophysectomized rats?

Population

Adult male Sprague-Dawley rats, hypophysectomized, receiving i.v. replacement therapy with L-thyroxine and cortisol

Intervention

Human growth hormone (hGH) given as a continuous i.v. infusion for 5 days

Comparator

Human growth hormone (hGH) given as eight daily pulses (3-h intervals) for 5 days

Outcome

Serum concentrations of cholesterol and apolipoprotein Esurrogate

The sexually dimorphic secretory pattern of growth hormone regulates serum HDL-cholesterol and ApoE concentrations in rats.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Should not alter GH dosing in patients; leaves open whether secretory pattern affects human lipid profiles.

Cite This Study

Oscarsson et al. (1991) studied this question.

synapsesocial.com/papers/6a7a20cce357fbdac5895f67 https://doi.org/10.1677/joe.0.1280433

View Full Paper

Ask AI

Bookmark

Evidence for the role of the secretory pattern of growth hormone in the regulation of serum concentrations of cholesterol and apolipoprotein E in rats

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Evidence for the role of the secretory pattern of growth hormone in the regulation of serum concentrations of cholesterol and apolipoprotein E in rats

Key Points

Structured PICO

Discussion

Implication

Cite This Study

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