Why the study?
Does carvedilol improve left ventricular function, remodeling, and survival in rats surviving a large myocardial infarction?
Does carvedilol improve left ventricular function, remodeling, and survival in rats surviving a large myocardial infarction?
In a rat model of large myocardial infarction, high-dose carvedilol preserved LV function and reduced fibrosis but paradoxically increased early mortality.
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Alerts to potential harm from high-dose carvedilol post-MI in rats; leaves open dose optimization for survival benefit in preclinical models.
Sia et al. (2002) studied this question.
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