Why the study?
Does carvedilol improve hemodynamics and reduce myocardial fibrosis in a rat model of dilated cardiomyopathy?
Population
Lewis rats with dilated cardiomyopathy induced by autoimmune myocarditis
Comparison
Carvedilol 2 mg/kg/day or 20 mg/kg/day orally… vs Vehicle (0.5% methylcellulose) orally for 2 months
Design
Preclinical
Follow-up
2 months
Authors
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No immediate clinical implications; hypothesis-generating for carvedilol in dilated cardiomyopathy.
Does carvedilol improve hemodynamics and reduce myocardial fibrosis in a rat model of dilated cardiomyopathy?
Low-dose carvedilol demonstrates beneficial effects on hemodynamics and myocardial fibrosis in a rat model of dilated cardiomyopathy.
Watanabe et al. (2000) studied this question.
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