Why the study?
Does carvedilol prevent cardiac remodeling and myopathies in stroke-prone spontaneously hypertensive rats on a salt-fat diet?
Population
33 stroke-prone spontaneously hypertensive rats (n=7-9 per group)
Comparison
Carvedilol 1200 or 2400 ppm supplemented to a… vs Salt-fat diet without carvedilol, and a normal…
Design
Preclinical
Follow-up
18 weeks
Authors
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Carvedilol may confer BP-independent cardioprotection in this hypertensive rat model; leaves open translation to human cardiac remodeling prevention.
Does carvedilol prevent cardiac remodeling and myopathies in stroke-prone spontaneously hypertensive rats on a salt-fat diet?
Carvedilol provides significant cardioprotection against severe hypertension-induced cardiac remodeling and myopathies independent of blood pressure reduction in a rat model.
Barone et al. (1998) studied this question.
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