Key result
A step-by-step guide was developed for implementing Targeted Maximum Likelihood Estimation (TMLE) for continuous outcomes using an openly accessible clinical dataset.
Why the study?
Targeted maximum likelihood estimation avoids strict model specification assumptions, but accessible resources for implementation in continuous outcomes using real clinical data are lacking.
Population
An openly accessible clinical dataset
Design
Tutorial and step-by-step implementation guide
Authors
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TMLE may aid causal estimation in observational data; leaves open superiority over standard methods in practice.
This paper provides a practical, step-by-step guide for implementing Targeted Maximum Likelihood Estimation (TMLE) for continuous outcomes, addressing a gap in accessible resources for epidemiologists and analysts.
Frank et al. (2023) studied this question. Targeted Maximum Likelihood Estimation (TMLE) was evaluated. A step-by-step guide was developed for implementing Targeted Maximum Likelihood Estimation (TMLE) for continuous outcomes using an openly accessible clinical dataset.
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