What a contrast! Agents for both magnetic resonance imaging (MRI) and near-infrared (NIR) fluorescence imaging are synthesized by encapsulating iron oxide nanoparticles and indocyanine green in a poly(lactide-co-glycolide) matrix. The migration of dendritic cells (DCs) via lymphatic drainage is monitored by real-time NIR fluorescence imaging, and the tracking of DCs into lymph nodes is achieved through noninvasive MRI (see picture).
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Lim et al. (2008) studied this question.
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