Key result
This review analyzes the pathophysiological mechanisms underlying cardiovascular toxicity associated with chemotherapy and radiation therapy in cancer patients.
Why the study?
Improved cancer survival has increased long-term cardiovascular complications from chemo- and radiation therapy, requiring an understanding of toxic mechanisms and drug interactions.
Understanding the pathophysiological mechanisms of cardiovascular toxicity from cancer therapies is essential for comprehensive prevention and management in cardio-oncology.
Increasing CV complications in cancer survivors warrant integrated cardio-oncology care; leaves optimal prevention strategies open.
The review presents an analysis of current literature data demonstrating the pathophysiological mechanisms of the development of cardiovascular complications of chemo- and radiation therapy in cancer patients. The undoubted successes achieved in the treatment of oncological diseases can improve survival and reduce mortality. However, there was a problem of increasing cardiovascular complications during long-term treatment, due to various toxic side effects of chemo- and radiation therapy from the cardiovascular system. For comprehensive prevention and treatment, as well as to improve the prognosis, it is necessary to understand the mechanisms and interactions of drugs underlying the interstitial curation of cancer patients. The purpose of this review is to analyze literature sources illustrating the pathophysiological mechanisms of cardiovascular toxicity in the appointment of chemotherapy and radiation therapy in clinical practice in cancer patients.
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Bespalov et al. (2022) conducted a review in Cancer. Chemotherapy and radiation therapy was evaluated. This review analyzes the pathophysiological mechanisms underlying cardiovascular toxicity associated with chemotherapy and radiation therapy in cancer patients.
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