November 1, 1992AJP Heart and Circulatory Physiology
Development of cardiac innervation, ventricular fibrillation, and sudden infant death syndrome
Population
Three groups of puppies (1, 3, and 5 weeks old) and one group of adult dogs
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Autonomic effects on ventricular stability in developing hearts warrant no clinical change; leaves open mechanistic links to sudden infant death.
Structured PICO
P
Population
Three groups of puppies (1, 3, and 5 weeks old) and one group of adult dogs
I
Intervention
Bilateral vagotomy, right stellectomy, left stellectomy, and bilateral stellectomy
O
Outcome
Ventricular fibrillation threshold (VFT) and heart ratesurrogate
Removal of vagal or right sympathetic activity increases susceptibility to ventricular fibrillation early in life, whereas left sympathetic removal increases electrical stability, suggesting a potential mechanism for sudden infant death syndrome.
Cite This Study
Stramba‐Badiale et al. (1992) studied this question.