Key result
Left stellate ganglionectomy reduced the incidence of spontaneous sustained monomorphic ventricular tachycardia compared to control (7% vs 33%, P=0.06) in postinfarction dogs.
Why the study?
Does left stellate ganglionectomy reduce spontaneous sustained ventricular tachycardia in dogs following coronary artery ligation?
Population
Dogs undergoing left anterior descending coronary artery ligation
Comparison
Left stellate ganglionectomy performed 15… vs Control group and right stellate ganglionectomy…
Design
Preclinical
Follow-up
24 hours
Authors
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May reduce postinfarction VT in dogs; hypothesis-generating and should not inform human practice without trials.
Does left stellate ganglionectomy reduce spontaneous sustained ventricular tachycardia in dogs following coronary artery ligation?
Absolute Event Rate: 7% vs 33%
p-value: p=0.06
Left stellate ganglionectomy reduces triggers for spontaneous sustained ventricular tachycardia without altering the underlying reentrant substrate in a postinfarction dog model.
Patterson et al. (1991) studied Postinfarction (left anterior descending coronary artery ligation) (n=81). Left stellate ganglionectomy vs. Control and right stellate ganglionectomy was evaluated on Incidence of spontaneous sustained monomorphic ventricular tachycardia (p=0.06). Left stellate ganglionectomy reduced the incidence of spontaneous sustained monomorphic ventricular tachycardia compared to control (7% vs 33%, P=0.06) in postinfarction dogs.
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