What is the clinical evidence from this study?

Study design: Cohort. Population: Cardiovascular disease risk (n=24014). Intervention: Age and sex. Primary outcome: Ratio of 10-year total CVD to 10-year CVD mortality stratified by age and sex (Ratio 5.4).

August 10, 2015HeartOpen Access

Estimated 10-year cardiovascular mortality seriously underestimates overall cardiovascular risk

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Key result

The overall ratio of 10-year total CVD to CVD mortality was 5.4, with major variations by age and sex, demonstrating that a fixed multiplier of 3 seriously underestimates overall cardiovascular risk.

Population

24,014 men and women aged 39-79 years without baseline cardiovascular disease or diabetes mellitus in the…

Design

Cohort

Follow-up

10 years

Authors

HJH T JørstadPreventive Cardiology ECErsen B ColkesenSt. Antonius Ziekenhuis SBS. Matthijs BoekholdtCardiac Imaging

Discussion

Member takes

Implication

Challenges use of fixed multipliers in CVD risk estimation; leaves open refinement of prognostic tools by age and sex.

Study Design

Type

Cohort (n=24,014)

Structured PICO

Population

24,014 men and women aged 39-79 years without baseline cardiovascular disease or diabetes mellitus, evaluated for 10-year cardiovascular outcomes.

Outcome

Ratio of 10-year total CVD (fatal plus non-fatal CVD requiring hospitalisation) to 10-year CVD mortality stratified by age and sexcomposite

Main Result

Effect estimate: Ratio 5.4

The relationship between 10-year total CVD and CVD mortality is highly dependent on age and sex, demonstrating that using a fixed multiplier seriously underestimates overall cardiovascular risk, particularly in younger individuals and women.

Cite This Study

Jørstad et al. (2015) conducted a cohort in Cardiovascular disease risk (n=24,014). Age and sex was evaluated on Ratio of 10-year total CVD to 10-year CVD mortality stratified by age and sex (Ratio 5.4). The overall ratio of 10-year total CVD to CVD mortality was 5.4, with major variations by age and sex, demonstrating that a fixed multiplier of 3 seriously underestimates overall cardiovascular risk.

synapsesocial.com/papers/6a7a2d83756812e3958975c0 https://doi.org/10.1136/heartjnl-2015-307668

Topics

Women and heart disease Cardiovascular prevention

View Full Paper

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August 10, 2015HeartOpen Access

Estimated 10-year cardiovascular mortality seriously underestimates overall cardiovascular risk

View Full Paper

Ask AI

Bookmark

Key result

The overall ratio of 10-year total CVD to CVD mortality was 5.4, with major variations by age and sex, demonstrating that a fixed multiplier of 3 seriously underestimates overall cardiovascular risk.

Population

24,014 men and women aged 39-79 years without baseline cardiovascular disease or diabetes mellitus in the…

Design

Cohort

Follow-up

10 years

Authors

HJH T JørstadPreventive Cardiology ECErsen B ColkesenSt. Antonius Ziekenhuis SBS. Matthijs BoekholdtCardiac Imaging

Discussion

Member takes

Implication

Challenges use of fixed multipliers in CVD risk estimation; leaves open refinement of prognostic tools by age and sex.

Study Design

Type

Cohort (n=24,014)

Structured PICO

Population

24,014 men and women aged 39-79 years without baseline cardiovascular disease or diabetes mellitus, evaluated for 10-year cardiovascular outcomes.

Outcome

Ratio of 10-year total CVD (fatal plus non-fatal CVD requiring hospitalisation) to 10-year CVD mortality stratified by age and sexcomposite

Main Result

Effect estimate: Ratio 5.4

Cite This Study

synapsesocial.com/papers/6a7a2d83756812e3958975c0 https://doi.org/10.1136/heartjnl-2015-307668

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Topics

Women and heart disease Cardiovascular prevention

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