Angina frequency after acute myocardial infarction in patients without obstructive coronary artery disease
Key result
Absence of obstructive coronary artery disease post-MI was associated with a similar risk of angina compared to obstructive disease (IRR 0.89; 95% CI 0.77-1.02).
Why the study?
Does the absence of obstructive CAD affect angina frequency post-MI compared to the presence of obstructive CAD?
Population
5,539 MI patients who underwent angiography from 31 US hospitals. 6.9% had no angiographic obstructive CAD.
Comparison
Absence of obstructive CAD vs Presence of obstructive CAD
Design
Cohort
Follow-up
12 months
Authors
Discussion
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Implication
Supports similar post-MI angina management regardless of CAD; hypothesis-generating for etiology-specific therapies.
Study Design
Type
Cohort (n=5,539)
Multicenter
Yes
Structured PICO
Does the absence of obstructive CAD affect angina frequency post-MI compared to the presence of obstructive CAD?
P
Population
5,539 myocardial infarction patients who underwent angiography from 31 US hospitals, followed for 12 months.
E
Exposure
Absence of obstructive CAD (defined as epicardial stenoses >70% or left main >50%)
C
Comparator
Presence of obstructive CAD
O
Outcome
Angina frequency assessed at baseline, 1, 6, and 12 months using the Seattle Angina Questionnaire (SAQ)patient reported
Main Result
Relative Risk: 0.89 (95% CI 0.77–1.02)
Patients with MI but no obstructive CAD experience a similar burden of post-MI angina as those with obstructive CAD, highlighting the need for effective anti-anginal strategies in this population.
Cite This Study
Grodzinsky et al. (2015) conducted a cohort in Myocardial infarction (n=5,539). Absence of obstructive coronary artery disease vs. Obstructive coronary artery disease was evaluated on Post-MI angina (IRR 0.89, 95% CI 0.77-1.02). Absence of obstructive coronary artery disease post-MI was associated with a similar risk of angina compared to obstructive disease (IRR 0.89; 95% CI 0.77-1.02).