Key result
At 1-year follow-up, the revised surgical strategy for tetralogy of Fallot total correction significantly improved the pressure gradient at the right ventricular outflow tract from 82.0 to 26.8 mmHg.
Why the study?
Does a revised surgical strategy preserving the pulmonary valve and avoiding right ventriculotomy improve echocardiographic outcomes and reduce pulmonary regurgitation in pediatric patients undergoing tetralogy of Fallot total correction?
Observational (n=27)
No
Does a revised surgical strategy preserving the pulmonary valve and avoiding right ventriculotomy improve echocardiographic outcomes and reduce pulmonary regurgitation in pediatric patients undergoing tetralogy of Fallot total correction?
Absolute Event Rate: 26.8% vs 82%
p-value: p=<0.001
A revised surgical strategy for tetralogy of Fallot total correction that preserves the pulmonary valve and avoids right ventriculotomy yields acceptable short-term pulmonary valve function and growth without significant pulmonary regurgitation.
May limit early PR and preserve RV function in TOF repair; leaves open long-term validation in larger cohorts.
BACKGROUND: We reviewed our revised surgical strategy for tetralogy of Fallot (TOF) total correction to minimize early exposure to significant pulmonary regurgitation (PR) and to avoid right ventriculotomy (RV-tomy). METHODS AND RESULTS: Since February 2016, we have tried to preserve, first, pulmonary valve (PV) function to minimize PR by extensive commissurotomy with annulus saving; and second, RV infundibular function by avoiding RV-tomy. With this strategy, we performed total correction for 50 consecutive patients with TOF until May 2018. We reviewed the early outcomes of 27 of 50 patients who received follow-up for ≥3 months. Mean patient age at operation was 10.2±5.0 months, and mean body weight was 8.8±1.2 kg. The preoperative pressure gradient at the RV outflow tract and the PV z-score were improved at most recent echocardiography from 82.0±7.1 to 26.8±6.4 mmHg, and from -2.35±0.49 to -0.55±0.54, respectively, during 11.1±1.6 months of follow-up after operation. One patient required re-intervention for residual pulmonary stenosis. Twenty-two patients had less than moderate PR (none, 1; trivial, 8; mild, 13), and 5 patients had moderate PR. There was no free or severe PR. CONCLUSIONS: At 1-year follow-up, the patients who underwent total TOF correction with our revised surgical strategy had acceptable results in terms of PV function. The preserved PV had a tendency to grow on short-term follow-up.
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Kwak et al. (2018) conducted an observational in Tetralogy of Fallot (n=27). Revised surgical strategy (pulmonary valve preservation and avoiding right ventriculotomy) vs. Preoperative baseline was evaluated on Pressure gradient at the right ventricular outflow tract (RVOT) (p=<0.001). At 1-year follow-up, the revised surgical strategy for tetralogy of Fallot total correction significantly improved the pressure gradient at the right ventricular outflow tract from 82.0 to 26.8 mmHg.
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