Why the study?
The study was conducted to review long-term outcomes following tetralogy of Fallot repair with trans-annular incision and to evaluate the effectiveness of pulmonary valve replacement on those outcomes.
Does pulmonary valve replacement improve survival and reduce adverse events in patients with repaired tetralogy of Fallot with trans-annular incision?
Population
180 patients who underwent total correction for TOF with trans-annular incision
Comparison
PVR group vs non-PVR group
Design
Retrospective review
Follow-up
More than 20 years
Key result
Pulmonary valve replacement was associated with a significantly higher 20-year overall survival rate (100% vs 88.7%) compared to no replacement in patients with repaired tetralogy of Fallot.
Authors
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PVR after transannular TOF repair was associated with higher 20-year survival; leaves open whether routine PVR improves outcomes in modern practice.
Cohort (n=180)
No
Does pulmonary valve replacement improve survival and reduce adverse events in patients with repaired tetralogy of Fallot with trans-annular incision?
Absolute Event Rate: 100% vs 88.7%
p-value: p=0.007
In patients with repaired tetralogy of Fallot with trans-annular incision, subsequent pulmonary valve replacement is associated with improved 20-year survival and reduced adverse events.
Kwak et al. (2021) conducted a cohort in Repaired Tetralogy of Fallot with trans-annular incision (n=180). Pulmonary valve replacement (PVR) vs. Non-pulmonary valve replacement (non-PVR) was evaluated on Overall survival rate at 20 years (p=0.007). Pulmonary valve replacement was associated with a significantly higher 20-year overall survival rate (100% vs 88.7%) compared to no replacement in patients with repaired tetralogy of Fallot.
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