Key result
Pulmonary valve replacement in patients with repaired tetralogy of Fallot demonstrated long-term safety, with 95% transplantation-free survival and 90% freedom from adverse clinical events at 15 years.
Why the study?
To evaluate long-term outcomes of pulmonary valve replacement in patients with repaired tetralogy of Fallot and identify factors associated with adverse clinical events.
Population
190 patients who underwent PVR between 1998 and 2015 after repair of TOF
Design
Retrospective cohort study
Follow-up
Median 9.8 years
Authors
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Supports PVR evaluation in repaired TOF; leaves open optimal timing from prospective trials.
Cohort (n=190)
Pulmonary valve replacement in patients with repaired tetralogy of Fallot demonstrates excellent long-term outcomes, with 95% transplantation-free survival at 15 years, supporting proactive intervention before advanced ventricular dysfunction.
Lee et al. (2020) conducted a cohort in Repaired tetralogy of Fallot (TOF) (n=190). Pulmonary valve replacement was evaluated on Freedom from adverse clinical events (all-cause death, heart transplantation or new-onset sustained arrhythmia) at 15 years. Pulmonary valve replacement in patients with repaired tetralogy of Fallot demonstrated long-term safety, with 95% transplantation-free survival and 90% freedom from adverse clinical events at 15 years.
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