Why the study?
Adults undergoing TOF repair face higher mortality and PR-related complications, and while PVR improves symptoms, its effect when performed concomitantly with repair on mid-term RV parameters and bioprosthetic durability was unclear.
Does concomitant pulmonary valve replacement with intracardiac repair preserve right ventricular function and functional status in adolescents and adults with tetralogy of Fallot and hypoplastic pulmonary annulus?
Population
37 adolescents and adults with TOF and hypoplastic pulmonary annulus
Comparison
Concomitant TOF repair with PVR
Design
Retrospective single-institute cohort study
Follow-up
Mean 53.3 ± 16.4 months
Key result
Concomitant pulmonary valve replacement with TOF repair resulted in 0% early or late mortality and preserved RV function and functional status at a mean follow-up of 53.3 months.
Authors
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Supports feasibility of concomitant PVR in TOF repair; hypothesis-generating pending controlled trials.
Observational (n=37)
No
Does concomitant pulmonary valve replacement with intracardiac repair preserve right ventricular function and functional status in adolescents and adults with tetralogy of Fallot and hypoplastic pulmonary annulus?
Concomitant pulmonary valve replacement with tetralogy of Fallot repair in adolescents and adults provides excellent mid-term outcomes, preserving right ventricular function and functional status with minimal valve degeneration.
Jain et al. (2021) conducted an observational in Tetralogy of Fallot (n=37). Concomitant pulmonary valve replacement with TOF repair was evaluated on Right ventricular parameters, cardiopulmonary exercise capacity, and bioprosthetic valve durability. Concomitant pulmonary valve replacement with TOF repair resulted in 0% early or late mortality and preserved RV function and functional status at a mean follow-up of 53.3 months.
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