Key result
Endothelins activate NADPH oxidases via the ET receptor-Pyk2-Rac1 pathway, increasing superoxide production and oxidative stress, which may mediate cardiovascular dysfunction.
This review highlights the complex, bidirectional relationship between the endothelin system and NADPH oxidases in cardiovascular pathophysiology.
Endothelin-NADPH oxidase signaling may contribute to cardiovascular oxidative stress; leaves open whether targeted inhibition improves outcomes.
The endothelin (ET) system and NADPH oxidase play important roles in the regulation of cardiovascular function, as well as in the pathogenesis of hypertension and other cardiovascular diseases. 2. Endothelins activate NADPH oxidases and thereby increase superoxide production, resulting in oxidative stress and cardiovascular dysfunction. Thus, NADPH oxidases may mediate the role of endothelins in some cardiovascular diseases. However, the role of reactive oxygen species (ROS) in mediating ET-induced vasoconstriction and cardiovascular disease remains under debate, as evidenced by conflicting reports from different research teams. Conversely, activation of NADPH oxidase can stimulate ET secretion via ROS generation, which further enhances the cardiovascular effects of NADPH oxidase. However, little is known about how ROS activate the endothelin system. It seems that the relationship between ET-1 and ROS may vary with cardiovascular disorders. 3. Endothelins activate NADPH oxidase via the ET receptor-proline-rich tyrosine kinase-2 (Pyk2)-Rac1 pathway. Rac1 is an important regulator of NADPH oxidase. There is ample evidence supporting direct stimulation by Rac1 of NADPH oxidase activity. In addition, Rac1-induced cardiomyocyte hypertrophy is mediated by the generation of ROS.
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Dammanahalli et al. (2007) conducted a review in Cardiovascular diseases and hypertension. Endothelins and NADPH oxidases was evaluated. Endothelins activate NADPH oxidases via the ET receptor-Pyk2-Rac1 pathway, increasing superoxide production and oxidative stress, which may mediate cardiovascular dysfunction.
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