Key result
Elevated circulating levels of reticulated platelets were associated with a significantly higher risk of composite cardiovascular events (RR 2.00) in patients with coronary artery disease, even after adjusting for conventional prognostic factors.
Why the study?
Preliminary studies suggested circulating levels of reticulated platelets were associated with cardiovascular events in patients with CAD, but their prognostic value required systematic evaluation.
Does an elevated level of reticulated platelets predict cardiovascular events in patients with coronary artery disease?
Meta-Analysis (n=1,636)
Does an elevated level of reticulated platelets predict cardiovascular events in patients with coronary artery disease?
Relative Risk: 2 (95% CI 1.3–3.08)
p-value: p=<0.00001
Elevated circulating levels of reticulated platelets are associated with a significantly higher risk of composite cardiovascular events and cardiovascular death in patients with coronary artery disease.
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Supports RP measurement for CVE risk stratification in CAD; leaves open need for prospective validation and therapeutic targeting.
Zhao et al. (2020) conducted a meta-analysis in Coronary Artery Disease (n=1,636). Elevated reticulated platelets vs. Low reticulated platelets was evaluated on Composite cardiovascular events (RR 2.00, 95% CI 1.30-3.08, p=<0.00001). Elevated circulating levels of reticulated platelets were associated with a significantly higher risk of composite cardiovascular events (RR 2.00) in patients with coronary artery disease, even after adjusting for conventional prognostic factors.
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